Hierarchical co-regulation

Gene Co-regulation vs. Co-expression

Foundations for Continuous Time Hierarchical Co-simulation

Complex systems have to decomposed into sub-systems which are developed by specialized teams. Modeling and simulation techniques help each team achieve a locally optimal solution but they fail to help all teams achieve a globally optimal solution. This is due to each team having its own models made in its own tools, and external suppliers having intellectual property. The result is that it is d...

Co-Evolving Line Drawings with Hierarchical Evolution

We use an adversarial approach inspired by biological coevolution to generate complex line drawings without human guidance. Artificial artists and critics work against each other in an iterative competitive framework, forcing each to become increasingly sophisticated to outplay the other. Both the artists and critics are implemented in hercl, a framework combining linear and stack-based Genetic...

Hierarchical Co-Clustering of Artists and Tags

The user-assigned tag is a growingly important research topic in MIR. Noticing that some tags are more specific versions of others, this paper studies the problem of organizing tags into a hierarchical structure by taking into account the fact that the corresponding artists are organized into a hierarchy based on genre and style. A novel clustering algorithm, Hierarchical Co-clustering Algorith...

Hierarchical regulation of WASP/WAVE proteins.

Members of the Wiskott-Aldrich syndrome protein (WASP) family control actin dynamics in eukaryotic cells by stimulating the actin nucleating activity of the Arp2/3 complex. The prevailing paradigm for WASP regulation invokes allosteric relief of autoinhibition by diverse upstream activators. Here we demonstrate an additional level of regulation that is superimposed upon allostery: dimerization ...